Important notice

Meds75+ – information regarding the use for persons aged 75+

Substances A-Z
  • Ac

  • Acidum acetylsalicylicum
    Used as "ANALGESICS"
    Class D
    Avoid use in older persons. Not suitable for pain treatment. Reduce the dose in moderate renal insufficiency. Do not use in severe renal insufficiency. Significant adverse effects include bleeding and damage of gastric mucosa. May reduce the effect of antihypertensives and drugs used for cardiac insufficiency. Increases the toxicity of methotrexate. Note acetylsalicylic acid in OTC drugs and combination products.
    Class C
    Suitable for older persons, with specific cautions. A significant adverse effect is increased risk of bleeding.
  • Al

  • Alprazolamum
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Sedative. A long-acting. Significant adverse effects include drug addiction, cognitive disorder and risk for traffic accidents. Increases risk for falls. Paradoxically, may increase anxiety, restlessness and aggression.
  • Am

  • Amiodaroni hydrochloridum
    Used as "CARDIAC THERAPY"
    Class D
    Avoid use in older persons. Only a physician experienced in the treatment of severe arrhythmias may start the treatment. Risk of QT prolongation. Elimination is very slow. Significant adverse effects include hypo- or hyperthyroidism, alterations in the lungs, hepatic insufficiency and torsades de pointes ventricular tachycardia. Take several interactions into account.
  • Amitriptylini hydrochloridum
    Class D
    Avoid use in older persons. Anticholinergic. Sedative. Serotonergic. Risk of QT prolongation. Low doses (10-20mg) can be used for treating neuropathic pain. Significant adverse effects include confusion, cognitive disorder, tremor, arrhytmia, tachycardia, orthostatic hypotension and serotonin syndrome. Increases risk for falls. Take several interactions into account. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Ba

  • Baclofenum
    Class D
    Avoid use in older persons. Reduce the dose in even mild renal insufficiency. Significant adverse effects include tiredness, confusion, depression, nightmares, muscular weakness, hypotension and risk for falls. May potentiate the sedative effects of other simultaneously used drugs affecting the CNS.
  • Bi

  • Bisacodylum
    Class D
    Avoid use in older persons. A laxative that stimulates the intestine. Can be used temporary. Risk of paralytic ileus in prolonged use.
  • Ch

  • Chlordiazepoxidum
  • Ci

  • Ciprofloxacinum
    Class D
    Avoid use in older persons. Risk of QT prolongation. Reduce the dose and/or increase the dosing interval in even moderate renal insufficiency. Increases the risk of tendinitis and aortic injury and valvular heart disease. Take significant interactions in the absorption phase into account, especially with iron, magnesium, aluminium, calcium and zinc. Take into account central nervous system adverse effects, especially lowered convulsive treshold and confusion.
  • Cl

  • Clarithromycinum
    Class D
    Avoid using in older persons. Reduce the dose in renal or hepatic insufficiency. Risk of QT prolongation. Take significant interactions into account.
  • Clomipramini hydrochloridum
    Class D
    Avoid use in older persons. Anticholinergic. Sedative. Serotonergic. Significant adverse effects include confusion, cognitive disorder, tremor, tachycardia, orthostatic hypotension and serotonin syndrome. Increases risk for falls. Take several interactions into account. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Clonazepamum
    Used as "ANTIEPILEPTICS"
    Class D
    Avoid use in older persons. Sedative. A long-acting. Significant adverse effects include drug addiction, cognitive disorder and risk for traffic accidents. Increases risk for falls. Paradoxically, may increase anxiety, restlessness and aggression.
  • Clozapinum
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Anticholinergic. Sedative. For treatment of psychosis only. Use according to the authoritative safety guidelines. Take into account especially the follow-up of blood count. Significant adverse effects include cognitive disorder, confusion, extrapyramidal symptoms, orthostatic hypotension and risk of cardiovascular events. Increases risk for falls. Smoking reduces the effect of the drug. Take several interactions into account. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Co

  • Codeini phosphas hemihydricus
    Used as "ANALGESICS"
    Class D
    Avoid use in older persons. Opioid. Sedative. Prodrug. Genotype affects the response. Significant adverse effects include constipation, nausea, urinary difficulties and gallbladder problems. Increases risk of falling. Take interactions into account.
    Class D
    Avoid use in older persons. Opioid. Sedative. Prodrug. Genotype affects the response. Significant adverse effects include constipation, nausea, urinary difficulties and gallbladder problems. Increases risk of falling. Take interactions into account.
  • De

  • Desmopressini acetas
    Class D
    Avoid use in older persons. Risk of fluid retention and hyponatraemia. Initiation of therapy under specialist´s supervision is possible as treatment for ADH deficiency.
  • Dextromethorphani hydrobromidum
    Class D
    Avoid use in older persons. Serotonergic. Take significant adverse effects into account. Take interactions into account especially with benzodiazepines and memantine.
    Class D
    Avoid use in older persons. Serotonergic. Significant adverse effects include tremor, palpitations, headache, nausea, constipation, tiredness, dizziness and risk for falls. Take interactions into account especially with memantine.
  • Di

  • Diazepamum
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Sedative. A long-acting. Significant adverse effects include drug addiction, cognitive disporder and risk for traffic accidents. Increases risk for falls. Paradoxically, may increase anxiety, restlessness and aggression. Avoid consuming grapefruit during treatment.
  • Diltiazemi hydrochloridum
    Class D
    Avoid use in older persons. Use only in special cases. Significant adverse effects include constipation, bradycardia and swelling. Take interactions into account, especially with digoxin and beta blockers. Avoid consuming grapefruit during treatment.
  • Do

  • Doxylamini hydrogenosuccinas
    Class D
    Avoid use in older persons. Strongly anticholinergic. Sedative. Increases risk for falls. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Dy

  • Dydrogesteronum
    Class D
    Avoid use in older persons. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
  • Ep

  • Ephedrini hydrochloridum
    Class D
    Avoid use in older persons. Do not use on patients with an ischaemic heart disease. Avoid use in severe renal or hepatic insufficiency. Significant adverse effects include insomnia, tremor, palpitations, elevated blood pressure and urinary retention. Take interactions into account.
  • Es

  • Estradioli valeras
    Class D
    Systemic use: Avoid use in older persons. Contraindication is oestrogen-dependent cancer. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
    Class D
    Intravaginal therapy: Suitable for older persons. Systemic use: Avoid use in older persons. Contraindication is oestrogen-dependent cancer. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
  • Estradiolum hemihydricum
    Class D
    Intravaginal therapy: Suitable for older persons. Systemic use: Avoid use in older persons. Contraindication is oestrogen-dependent cancer. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
    Class D
    Systemic use: Avoid use in older persons. Contraindication is oestrogen-dependent cancer. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
  • Estriolum
    Class D
    Intravaginal therapy: Suitable for older persons. Systemic use: Avoid use in older persons. Contraindication is oestrogen-dependent cancer. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
  • Fe

  • Fesoterodini fumaras
    Used as "UROLOGICALS"
    Class D
    Avoid use in older persons. Anticholinergic. Reduce the dose in even moderate renal insufficiency. Significant adverse reactions include dry mouth, constipation, urinary difficulties, confusion and cognitive disorder. Take several interactions into account. Weakens the efficacy of anti-Alzheimer`s drugs. Avoid consuming grapefruit during treatment.
  • Fl

  • Fluvoxamini maleas
    Class D
    Avoid use in older persons. Serotonergic. Significant adverse effects include insomnia, headache, dizziness, nausea, tachycardia and hyponatraemia. Increases risk for falls. Take the several interactions into account, especially with preparations that increase risk of bleeding.
  • Gl

  • Glimepiridum
    Class D
    Avoid use in older persons. A long-acting sulphonylurea. Risk of adverse effects increases as the function of kidneys and liver decreases. Do not use in severe renal insufficiency. Take interactions into account. Note danger of prolonged hypoglycaemia.
  • Ha

  • Haloperidolum
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Risk of QT prolongation. Significant adverse effects include cognitive disorder, confusion, extrapyramidal symptoms, orthostatic hypotension and risk of cardiovascular events. Increases risk for falls. Non-pharmacological treatments are the first line approach in the management of behavioral and psychological symptoms of dementia.
  • In

  • Indometacinum
    Class D
    Avoid use in older persons. Do not use in severe renal insufficiency. Significant adverse effects include gastrointestinal bleeding, renal insufficiency and its worsening, elevated blood pressure, cardiac insufficiency, dizziness and psychosis. Take interactions into account, especially with other drugs that increase the risk of bleeding and with antihypertensive agents.
  • Ma

  • Magnesii hydroxidum
    Class D
    Avoid use in older persons. Inappropriate as antacid for older persons, use safer alternatives. Reduce the dose in even moderate renal insufficiency. Take the several interactions in the absorption phase into account.
  • Magnesii subcarbonas ponderosus
    Class D
    Avoid use in older persons. Inappropriate as antacid for older persons, use safer alternatives. Reduce the dose in even moderate renal insufficiency. Take the several interactions in the absorption phase into account.
  • Me

  • Medroxyprogesteroni acetas
  • Metamizolum natricum
  • Metoclopramidi hydrochloridum
    Class D
    Avoid use in older persons. Reduce the dose in even mild renal insufficiency. Significant adverse effects include extrapyramidal symptoms and confusion. Take interactions into account, especially with antipsychotics and dopamine agonists like levodopa.
  • Mo

  • Moxonidinum
    Class D
    Avoid using for elderly persons. Sedative. Reduce the dose in even mild renal insufficiency. Significant adverse effects include orthostatism, headache, drowsiness,and sleep disorders. Potentiates the effect of CNS depressants.
  • Ni

  • Nitrofurantoinum
    Class D
    Avoid use in older persons. Do not use in moderate and severe renal insufficiency. Take significant adverse effects into account, such as alterations in the lungs and peripheral neuropathy.
  • No

  • Norethisteroni acetas
    Class D
    Avoid use in older persons. In systemic use, take adverse effects into account, such as risk of cardiovascular diseases and venous thromboembolisms. Take interactions into account.
  • Ox

  • Oxybutynini hydrochloridum
    Used as "UROLOGICALS"
    Class D
    Avoid use in older persons. Anticholinergic. Significant adverse effects include dry mouth, constipation, tachycardia, urinary difficulties, confusion and cognitive disorder. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Oxybutyninum
    Used as "UROLOGICALS"
    Class D
    Avoid use in older persons. Anticholinergic. Significant adverse effects include dry mouth, constipation, tachycardia, urinary difficulties, confusion and cognitive disorder. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Pe

  • Pentoxifyllinum
    Class D
    Avoid use in older persons. Increase the dosing interval in moderate and severe renal insufficiency. Modest efficacy and may cause several adverse drug effects.
  • Pi

  • Pitofenoni hydrochloridum
  • Re

  • Repaglinidum
    Class D
    Avoid use in older persons. Risk of hypoglycaemia. Take several interactions into account.
  • Se

  • Sennae fructus angustifoliae
    Class D
    Avoid use in older persons. A laxative that stimulates the intestine. Can be used temporary. Risk of paralytic ileus in prolonged use.
  • So

  • Solifenacini succinas
    Used as "UROLOGICALS"
    Class D
    Avoid use in older persons. Anticholinergic. Reduce the dose in severe renal insufficiency. Significant adverse reactions include dry mouth, constipation, urinary difficulties, confusion, cognitive disorder and QTc prolongation. Take several interactions into account. Weakens the efficacy of anti-Alzheimer´s drugs.
  • Sotaloli hydrochloridum
    Class D
    Avoid use in older persons. Non-selective beta blocker. Risk of QT prolongation. Requires evaluation by a specialist. Reduce the dose in even mild renal insufficiency. Significant adverse effects include bradycardia and orthostatic hypotension. Take several interactions into account.
  • Te

  • Testosteroni decanoas
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Testosteroni isocaproas
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Testosteroni phenylpropionas
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Testosteroni propionas
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Testosteroni undecanoas
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Testosteronum
    Class D
    Avoid use in older persons. May be considered in cases of moderate or severe hypogonadism. Do not use on patients with prostate cancer. Note the risk of cardiovascular adverse reactions and possibility of psychiatric disorders.
  • Tr

  • Tramadoli hydrochloridum
    Used as "ANALGESICS"
    Class D
    Avoid use of tramadol and dexketoprofen in combination products in older persons. Opioid. Serotonergic. Prodrug. Genotype affects the response. Significant adverse effects include constipation, nausea, urinary difficulties, gallbladder problems and hyponatraemia. Increases risk of falling. Take interactions into account.
    Used as "ANALGESICS"
    Class D
    Avoid use in older persons. Opioid. Serotonergic. Prodrug. Genotype affects the response. Significant adverse effects include constipation, nausea, urinary difficulties, gallbladder problems and hyponatraemia. Increases risk of falling. Take interactions into account.
  • Trazodoni hydrochloridum
    Class D
    Avoid use in older persons. Sedative. Serotonergic. Consider another antidepressant for primary treatment. Increases risk for falls. Take interactions into account. Avoid consuming grapefruit during treatment.
  • Triazolamum
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Sedative. A short-acting. Significant adverse effects include drug addiction, rebound insomnia, amnesia, cognitive disorder and risk for traffic accidents. Increases risk for falls. Paradoxically, may increase anxiety, restlessness and aggression. Take several interactions into account. Avoid consuming grapefruit during treatment.
  • Ve

  • Verapamili hydrochloridum
    Class D
    Avoid use in older persons. Use only in special cases. Reduce the dose in even moderate renal insufficiency. Significant adverse effects include bradycardia, constipation, cardiac insufficiency and swelling. Take interactions into account, especially with digoxin and beta blockers. Avoid consuming grapefruit during treatment.
  • Zo

  • Zolpidemi tartras
    Used as "PSYCHOLEPTICS"
    Class D
    Avoid use in older persons. Sedative. Significant adverse effects include drug addiction, cognitive disporder and risk for traffic accidents. Increases risk for falls. Non-pharmacological treatments are primary in the treatment of insomnia.

Icon explanation

Class A A (green): Suitable for the older persons. The medicinal substance can be used as in younger patients. Changes due to aging do not affect the dose or frequency of administration, and the adverse reaction profile is not different from that of younger patients.

Class B B (grey): There is little research evidence, practical experience or efficacy in older persons.

Class C C (yellow): Suitable for older persons, with specific cautions. The medicinal substance can be used by older persons, but the dose might either have to be reduced, or the frequency of administration decreased due to mild or moderate renal insufficiency or a significant risk of interactions or adverse reactions.

Class D D (red): Avoid use in older persons. Use is possible only in exceptional cases or on a one-off basis. Changes due to aging predispose older persons to adverse or dangerous reactions to the drug. The risk of adverse reactions typically exceeds the benefits.

Meds75+ data source is Finnish Medicines Agency Fimea (licensed under CC BY 4.0).
Data updated on Mar 30, 2021.